ABSTRACT
In the current circumstances, when lakhs of people are dying as a result of the COVID-19 Pandemic, imposing lockdown and shutdown disrupts the socioeconomic conditions of the entire globe to the point that the country's backbone is compromised. A highly modified, effective sterilizing and disinfection system is essential to improve the country or human civilization. To combat the many adverse effects of radiation, not only on human health but also on the environment, ultra violet technology has been introduced. UV technology is also a source of radiation that has health risks;however, changes in wavelength can make the risk low. UVM-30A sensor module is used in the sanitization to detect UV irradiation in this study effort. An IoT-based system based on Arduino uno microcontroller, GSM A6 WiFi module, and UVM-30A is presented to create an automated implanted UV radiation detection device. © 2022 Wiley Periodicals LLC.
ABSTRACT
Blood is a very important resource for healthcare-based services and there has been a consistently increasing demand for it in most parts of the world. Poor volunteer-based collection system, high-risk of transfusion-transmitted infections, and emergence of new pathogens as evident from the ongoing Coronavirus Disease 2019 (COVID-19) pandemic are potential challenges to the global healthcare systems. It is imperative to explore safe and reliable alternatives to red cell transfusions. Ex vivo culture of red cells (cRBCs) from different sources such as hematopoietic stem cells (HSCs), pluripotent stem cells, and immortalized progenitors (e.g., BELA-2 cells) could revolutionize transfusion medicine. cRBC could be of great diagnostic and therapeutic utility. It may provide a backup in times of acute shortages in patients with rare blood groups, and in cases with multiple antibodies or sickle cell anemia. The CRISP-Cas9 system has been used to develop personalized, multi-compatible RBCs for diagnostic reagents and patients with multiple allo-antibodies. cRBC could be practically feasible for pediatric patients, who require small quantities of red cell transfusions. cRBC produced under good manufacturing practice (GMP) conditions has been reported to survive in human blood circulation for more than 26 days. Recently, a phase I randomized controlled clinical trial called RESTORE was initiated to assess the survival and recovery of cRBCs. However, feasible technological advancement is required to produce enough cRBCs for clinical use. It is crucial to identify sustainable sources for large-scale production of clinically useful cRBCs. Although the potential cost of one unit of cRBC is extrapolated to be around US$ 8000, it is a life-saving product for patients having rare blood groups and is a "ready to use" source of phenotype-matched, homogenous young red cells in emergency situations.
ABSTRACT
Introduction: Pomalidomide is a third-generation immunomodulatory drug approved for relapsed and/or refractory Multiple Myeloma (RRMM). In the phase 3 OPTIMISMM trial, pomalidomide, bortezomib, and dexamethasone demonstrated superior efficacy in patients with RRMM. PRIME study (CTRI/2019/10/021618) is testing this combination in Newly Diagnosed Multiple Myeloma (NDMM) Aim: To determine safety of Pomalidomide in combination with Bortezomib and dexamethasone (VPD) in NDMM Study design: A prospective, single arm, phase II study from a tertiary center. Both transplant eligible and ineligible patients with NDMM aged between 18-70 years are being recruited in the study. Patients with Plasma cell leukemia, POEMS and amyloidosis were excluded. The regimen consists of weekly Bortezomib 1.3mg/sq.m (subcutaneous), Tab. Pomalidomide 2-4mg once daily for 21days, and Tab Dexamethasone 20mg twice weekly, with the cycle repeating every 28 days, 9-12 cycles. Here we report the adverse events (AE) by NCI CTCAE v5.0, upon recruiting 26 patients, as predetermined in the study. Results: Of the proposed 45-50 patients, 26 patients were enrolled in the study between April 2020 to May 2021 and 23 (88.4%) have completed 4 cycles of VPD. The median age is 55years (18-70), and gender ratio 1:1. At disease presentation, bone lesions were the commonest (96.2%, n=25), IMWG high risk cytogenetics were seen in 42.4% (n=11), RISS-2 in 69.3% (n=18), IgG kappa paraproteinemia in 54% (n=14) patients and ECOG performance score 2-3 in 57.6%(n=15). Ten (38.5%) patients have completed 9 cycles, and 3 underwent auto-transplant (between Cycle 4 & 6). Protocol adherence was 96.1% (25/26 patients). Table-1 shows drug-induced toxicity, hematological toxicities were the commonest. Two patients withdrew consent in view of bortezomib-induced peripheral neuropathy. Serious adverse events (SAE) were reported in 9 (34.6%) patients and were considered unrelated to the regimen by the safety committee (PSVT=1, Bony pain=2, dyspnea=1, pneumonia=1, constipation=1, diarrhea=1, hypotension=1) and one death due to SARS-CoV2 pneumonia. Treatment delays of 2 weeks in 4 patients (SARS-CoV2 = 3, Syncope = 1) After 4 cycles (n=23), 6 (26%) patients were in stringent Complete Response (sCR), 17(74%) in Very Good partial response (VGPR) and 13 (56.5%) are Measurable Residual Disease (MRD) negative. Of 10 patients who completed cycle 9, 9 were MRD negative and 1 showed disease progression. Conclusion: Safety data from the PRIME study demonstrates that VPD regimen has a favorable tolerance profile in patients with NDMM. Early efficacy signals are encouraging, and recruitment continues. [Formula presented] Disclosures: Radhakrishnan: Dr Reddy's Laboratories: Honoraria, Membership on an entity's Board of Directors or advisory committees;Emcure Pharmaceuticals: Research Funding;Intas Pharmaceuticals: Research Funding;Janssen India: Honoraria;NATCO Pharmaceuticals: Research Funding;Novartis India: Membership on an entity's Board of Directors or advisory committees;Roche India: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding;AstraZeneca India: Honoraria, Speakers Bureau;Bristol-Myers-Squibb India: Membership on an entity's Board of Directors or advisory committees, Research Funding;Cipla Pharmaceuticals India: Research Funding;Aurigene: Speakers Bureau. Garg: Dr Reddys Laboratories: Honoraria, Speakers Bureau. Nair: Dr Reddy's Laboratories: Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau;Intas pharmaceuticals: Honoraria, Speakers Bureau;Mylan pharmaceuticals: Honoraria;Novartis India: Honoraria;Fresenius Kabi India: Honoraria;Cipla Pharmaceuticals: Honoraria, Speakers Bureau;Janssen India: Honoraria, Speakers Bureau. Chandy: Janssen: Honoraria;Pfizer: Honoraria;Intas Pharmaceuticals: Research Funding.
ABSTRACT
COVID-19 has been primarily regarded as a respiratory disease, and until a safer and effective treatment or vaccine becomes available, the prevention of COVID-19 may continue through interventions based on non-pharmaceutical measures such as maintaining of physical distances and use of personal protective equipment like facemasks, etc. Therefore, an attempt was made in this study to explore the drawbacks with the presently available facemasks for protection from COVID-19 viruses in the state of Odisha in India, and also to explore the possible opportunities for further development of these facemasks. The associated discomforts;strength, weaknesses, opportunities, and threats (SWOT) analysis of existing facemasks in Odisha;possible opportunities for "Make in India"of these facemasks;along with safer use have been analyzed with the help of interpretive structural modelling (ISM) approach followed by MICMAC analysis. Copyright © 2022, IGI Global.
ABSTRACT
In December 2019, there was a flare-up of the unidentified reason for pneumonia that overwhelmed the vast majority of the world. This infection has a place with β-corona virus, an enormous class of infections common in nature. On the 11th of February 2020, W.H.O named this disease as COVID-19 (Corona virus Disease 2019). This novel corona virus is to be believed to get spread from the bat and later on a human to human transmission. These patients gave indications of extreme pneumonia including fever, weakness, dry cough and respiratory trouble. Still, the exact mechanism of its approach has not been cleared yet. But it’s said to be the same as the previous strain of it like SARS-CoV and MERS-CoV. It has been affirmed that the COVID-19 also uses the cell section receptor i.e.;ACE2 as the SARS-CoV. The COVID-19 said to transmit starting with one then onto the next individual, so it is important to totally intrude on human-to-human transmission. Another method to control the spread is to avoid the diligence of corona viruses on inanimate surfaces because of various kinds of materials it can stay irresistible for 2 hours as long as 9 days. The typical standards are keeping up hydration and sustenance and controlling fever and cough. The typical standards are keeping up hydration and sustenance and controlling fever and cough. But still, the previously used antiviral drugs as well as like antibody and convalescent plasma as a potential therapy were used in the treatment.